Evidence map›Paper›PMID 42455903›Full record

ArticleScience translational medicine2026

CD4

Kjetil Bjornevik, João Vitor Mahler, Philippe A Bilodeau, Brit Ellen Rød, Gabriela Romanow, Takahisa Mikami, Monique Anderson, Natasha Bobrowski-Khoury, Huimin Zhu, James Nguyen and 9 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Interpreting Viral Associations in Neurodegenerative Diseases.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kjetil BjornevikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-2892-6986
João Vitor MahlerDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-0700-3517
Philippe A BilodeauDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-2672-554X
Brit Ellen RødNeuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen 5021, Norway.ORCID 0000-0003-2200-1525
Gabriela RomanowDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-3656-9851
Takahisa MikamiDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-1851-5259
Monique AndersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-7713-2878
Natasha Bobrowski-KhouryDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-6946-3711
Huimin ZhuDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-4340-1125
James NguyenDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ying SunDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Marcelo MatielloDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
David HousmanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bardia NourbakhshDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kjell-Morten MyhrNeuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen 5021, Norway.ORCID 0000-0002-0980-510X
Øivind TorkildsenNeuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen 5021, Norway.ORCID 0000-0001-5294-2866
Ludvig M SollidInstitute of Clinical Medicine, University of Oslo, Oslo 0318, Norway.ORCID 0000-0001-8860-704X
Michael LevyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-7969-8346
Natalia DrosuDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-6197-8887

Funding

The Immunopathogenesis of Familial Transverse Myelitis Due to Mutations in VPS37aR01AI153068 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Michael Levy · 2023 to 2026
$1.7M
NIAID NIH HHS R01 AI153068
6 · The paper itself

Abstract

Multiple sclerosis (MS) pathogenesis is linked to Epstein-Barr virus (EBV), but the underlying immune mechanisms remain unclear. Using an optimized T cell assay, we demonstrate that CD4

Indexed as

Antigens, ViralCD4-Positive T-LymphocytesHerpesvirus 4, HumanMultiple SclerosisAdultCD8-Positive T-LymphocytesEpstein-Barr Virus Nuclear AntigensFemaleHumansMaleMiddle AgedAntigens, ViralEBV-encoded nuclear antigen 1Epstein-Barr Virus Nuclear Antigens

Identifiers

PMID42455903
PMCPMC13374717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.