ArticleScience advances2026
Simultaneous measurements of translation rate and transcriptome uncovers linked regulation within an active bacterial cell population.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- 4-Hydroxy-3-Methyl-2-Alkenylquinoline Disrupts Temporospatial Control of Flagellar Assembly and Induces Transcriptomic Remodeling inMolecules (Basel, Switzerland) · 2026Article
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5 authors.
Funding
Abstract
Cell-to-cell variation within clonal bacterial populations provides bacterial communities with important advantages including opportunities for bet-hedging and metabolic division of labor. In recent years, the extent of bacterial heterogeneity has been documented both at the transcriptome level and with physiological measurements of cell growth rate and translation rate. However, methods that link physiological parameters to a single cell's full transcriptomic state are lacking, making it difficult to identify the regulatory mechanisms that couple physiology and transcriptional output. Here, we introduce a method that combines click chemistry-enabled labeling of nascent polypeptides to measure translation rates in single cells alongside microfluidic encapsulation and single-cell transcriptomic measurements, providing a tandem measurement of translation rate and transcriptome in thousands of single
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