Evidence map›Paper›PMID 42455745›Full record

ArticleOrganic letters2026

A Postsynthetic Strategy for Oligonucleotides Containing 2-Fluoro-adenine and Isoguanine Nucleobases.

Mimouna Madaoui, Jayanta Kundu, Dhrubajyoti Datta, Joel M Harp, Martin Egli, Muthiah Manoharan

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mimouna MadaouiAlnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, United States.
Jayanta KunduAlnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, United States.ORCID 0000-0003-2669-8112
Dhrubajyoti DattaAlnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, United States.ORCID 0000-0003-2077-1294
Joel M HarpDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.
Martin EgliDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.ORCID 0000-0003-4145-356X
Muthiah ManoharanAlnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, Massachusetts 02142, United States.ORCID 0000-0002-7931-1172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a strategy for the synthesis of DNA, RNA and 2'-

Indexed as

AdenineGuanineOligonucleotidesDNAMolecular StructureRNAAdenineDNAGuanineisoguanineOligonucleotidesRNA

Identifiers

PMID42455745
PMCPMC13411049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.