Evidence map›Paper›PMID 42455666›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Endosomal TPC1-mediated Ca

William J Burton, Alice Lin, Anthony J Morgan, Lianne C Davis, Cheng-Chang Chen, Antony Galione

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William J BurtonDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom.ORCID 0009-0000-3984-548X
Alice LinDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 100233, Taiwan.
Anthony J MorganDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom.ORCID 0000-0001-5152-3205
Lianne C DavisDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom.ORCID 0000-0002-6004-9610
Cheng-Chang ChenDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 100233, Taiwan.ORCID 0000-0003-1282-4026
Antony GalioneDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom.ORCID 0000-0002-4132-7646

Funding

National Science and Technology Council (NSTC) 113-2927-I-002-510National Science and Technology Council (NSTC) 114-2320-B-002-022-MY3National Taiwan University () NTU-114L7857UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/T01640X/1UKRI | Engineering and Physical Sciences Research Council (SRC) 2885841
6 · The paper itself

Abstract

Two-pore channel 1 (TPC1) is an endosomal Na

Indexed as

CalciumCalcium ChannelsEndosomesHomeostasisIronReceptors, TransferrinAnimalsHeLa CellsHumansMiceProtein TransportTwo-Pore ChannelsCalciumCalcium ChannelsIronReceptors, TransferrinTPCN1 protein, humanTwo-Pore Channelscalcium signalingiron homeostasismembrane traffickingtransferrintwo-pore channel

Identifiers

PMID42455666
PMCPMC13389572

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.