Evidence map›Paper›PMID 42455648›Full record

ArticleChemistry & biodiversity2026

Amides Derived From Sclareolide as Cytotoxic Agents.

Júnio G Silva, Amanda S de Miranda, Tatiane F Borgati, Samuel M G Lopes, Sophie Hoenke, Juliana de Oliveira Silva, Fernanda F S Oliveira, André Luiz Branco de Barros, Adriano de Paula Sabino, René Csuk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Júnio G SilvaDepartment of Chemistry, Campus Pampulha, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Amanda S de MirandaDepartment of Chemistry, Campus Pampulha, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Tatiane F BorgatiDepartment of Chemistry, Campus Pampulha, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Samuel M G LopesDepartment of Chemistry, Campus Pampulha, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Sophie HoenkeMartin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Juliana de Oliveira SilvaDepartment of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Fernanda F S OliveiraDepartment of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
André Luiz Branco de BarrosDepartment of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Adriano de Paula SabinoDepartment of Clinical and Toxicological Analyses, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
René CsukMartin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID https://orcid.org/0000-0001-7911-290X
Luiz C A BarbosaDepartment of Chemistry, Campus Pampulha, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-5395-9608

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 171783/2023-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 306873/2021-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 315750/2023-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-03059-21
6 · The paper itself

Abstract

Natural products remain an invaluable source of inspiration for anticancer drug discovery. Herein, a series of 25 sclareolide (SC)-derived drimanamides was assessed for cytotoxicity against the A375, HT29, MCF-7, A2780, and HeLa tumor cell lines using the SRB assay. Structure-activity relationship analysis suggested that the introduction of aryl or triazolyl moieties was associated with increased potency relative to SC. Compounds 1 and 4 exhibited the most favorable cytotoxic profiles, with EC

Indexed as

AmidesAntineoplastic AgentsDiterpenesApoptosisCell CycleCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAmidesAntineoplastic AgentsDiterpenesantitumoralcancerdrimanamidesnatural productssclareol

Identifiers

PMID42455648
PMCPMC13372051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.