ArticleChemistry & biodiversity2026
New Polyene Pregnane Steroids From the Stems of Nerium oleander: Structural Characterization and In Vitro Anti-Inflammatory Evaluation.
Tong-Xin Zheng, Zi-Xin Lin, He-Hui Zhan, Xin-Hong Wang, Xing-Wei Li, Cheng-Jun Huang, Li Liu, Yong-Mei Huang, Xiao-San Li, Hui Luo
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Tong-Xin ZhengGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.
Zi-Xin LinGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.
He-Hui ZhanGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.
Xin-Hong WangSchool of Pharmacy, Guangdong Medical University, Dongguan, P.R. China.
Xing-Wei LiThe First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.
Cheng-Jun HuangThe First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.
Li LiuSchool of Pharmacy, Guangdong Medical University, Dongguan, P.R. China.
Yong-Mei HuangGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.ORCID https://orcid.org/0000-0003-2926-4635 Xiao-San LiGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.ORCID https://orcid.org/0000-0001-8617-5968 Hui LuoGuangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, P.R. China.ORCID https://orcid.org/0000-0001-6121-1715 Funding
"Clinical + Basic" Scientific Innovation Special Project of Guangdong Medical University 4SG25311G"Clinical + Basic" Scientific Innovation Special Project of Guangdong Medical University 4SG25314G"Clinical + Basic" Scientific Innovation Special Project of Guangdong Medical University GDMUZDCG25020"Clinical + Basic" Scientific Innovation Special Project of Guangdong Medical University GDMUZDCG25023Economic Development of Marine Economy of Guangdong Province GDNRC [2022]38Undergraduate Innovation and Entrepreneurship Education Base Project of Guangdong Medical University JDXM2025122Undergraduate Innovation and Entrepreneurship Education Base Project of Guangdong Medical University JDXM2025133
6 · The paper itselfAbstract
Phytochemical investigation on the stems of Nerium oleander led to the isolation of four previously undescribed polyene pregnane steroids, namely neristerone A-D (1-4), together with six known analogues (5-10). Their structures were fully elucidated by extensive spectroscopic analysis (UV, IR, HR-ESI-MS, and NMR) and electronic circular dichroism (ECD) calculations. All isolates were evaluated for the inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Notably, compounds 1, 4, and 10 exhibited significant inhibitory activity with IC
Indexed as
Anti-Inflammatory AgentsNeriumPlant StemsPregnanesSteroidsAnimalsDose-Response Relationship, DrugLipopolysaccharidesMacrophagesMiceMolecular ConformationMolecular StructureNitric OxideRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsLipopolysaccharidesNitric OxidePregnanesSteroidsanti‐inflammation activitychemical constituentsNerium oleanderpregnanes
Identifiers
PMID42455645
PMCPMC13372049
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