Evidence map›Paper›PMID 42455473›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2026

Integrative machine learning reveals a TLS signature and CCL5-CCR1 axis-associated immune remodeling in breast cancer.

Chuyi Wang, Pengcheng Ding, Wei Ouyang, Yunhai Ding, Meilin Lu, Tianyi Li, Yunxing Xu, Liangfeng Zheng, Kai Chen, Feiyue Ji and 3 more

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Article in Cellular oncology (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Chuyi Wang *Department of Pathology, Affiliated Haian Hospital of Nantong University, Nantong, China.
Pengcheng Ding *Central Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Wei Ouyang *Department of Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yunhai Ding *Central Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Meilin LuCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Tianyi LiCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Yunxing XuCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Liangfeng ZhengCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Kai ChenCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Feiyue JiCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China.
Min DaiDepartment of Breast Center, Affiliated Haian Hospital of Nantong University, Nantong, China. daimin12@126.com.
Guiyuan GuDepartment of Pathology, Affiliated Haian Hospital of Nantong University, Nantong, China. ggy169828@163.com.
Xiaomin LuCentral Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, China. lxm122098624@ntu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is a critical but poorly understood step in breast cancer progression. This study characterizes the dynamic remodeling of the tumor microenvironment (TME) during this transition, focusing on tertiary lymphoid structures (TLS) and chemokine signaling.

methodsUsing an integrated multi-omics approach-including multiplex immunofluorescence of a clinical cohort, public single-cell and spatial transcriptomics data, and a longitudinal syngeneic mouse model (EO771)-we investigated spatiotemporal TME evolution.

resultsOur findings reveal that TLS reorganization during the DCIS-to-IDC shift is closely associated with the CCL5-CCR1 axis, which is implicated in macrophage-CD8

conclusionsThis work highlights CCL5-CCR1 axis-related TLS dysregulation as a key spatiotemporal feature of invasion, provides a clinically applicable prognostic signature for early risk stratification, and nominates actionable targets to intercept invasive progression.

Indexed as

Breast NeoplasmsChemokine CCL5Machine LearningReceptors, CCR1AnimalsFemaleGene Expression Regulation, NeoplasticHumansMiceSignal TransductionTumor MicroenvironmentCCR1 protein, humanChemokine CCL5Receptors, CCR1Breast cancerCCL5Ductal carcinoma in situMachine learningTertiary lymphoid structures

Identifiers

PMID42455473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.