ReviewAdvances in experimental medicine and biology2026
Oocyte Kinetochores at the Nexus of Meiotic Drive and Segregation Fidelity.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Faithful chromosome segregation in oocytes relies on the precise coordination of core centromeric chromatin, dynamic kinetochore assembly, and spindle interactions. In meiosis I, sister kinetochores are mono-oriented toward the same spindle pole, allowing homologous chromosomes to bi-orient and segregate properly, whereas meiosis II exhibits conventional bi-orientation of sister chromatids. Stepwise assembly of kinetochore subcomplexes, Meikin-mediated mono-orientation, and protection of centromeric cohesion by Shugoshin ensure accurate segregation through meiotic divisions. These same structural and regulatory features, however, are also exploited by selfish centromeres to bias chromosome orientation on the oocyte spindle, leading to biased segregation to the egg and therefore to the next generation in violation of Mendel's Law of Segregation. We will review recent studies that have established a mechanistic framework for both accurate chromosome segregation and non-Mendelian segregation in oocytes, highlighting the central role of meiotic centromeres in female reproduction and evolutionary conflict.
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