SynthesisSports medicine - open2026
Exercise Training in Hypertrophic Cardiomyopathy: A Systematic Review, Meta-analysis, and Meta-regression.
Synthesis in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
backgroundA paradigm shift has emerged regarding exercise participation in patients with hypertrophic cardiomyopathy (HCM), with recent studies suggesting that structured training may improve functional capacity and cardiopulmonary responses. However, the effects of structured exercise interventions in HCM have not been comprehensively synthesized.
aimThe main objective was to determine the effect of exercise training on bodyweight, functional capacity, echocardiography, blood pressure, heart rate (HR), double product, and NT-proBNP in HCM patients.
methodsRandomized controlled trials (RCTs) and non-randomized individualized endurance and concurrent training interventions including cardiopulmonary exercise test and echocardiographic measures in adult (≥ 18 years) obstructive and non-obstructive HCM patients were extracted from PubMed, Web of Science, and Cochrane in December 2025. Random-effects meta-analyses and meta-regressions were performed, and risk of bias was assessed using the ROBINS-I V2 tool for internal validity.
resultsData from 8 studies (3 RCTs) with 205 low to moderate risk patients showed that training significantly (all p < 0.05) increased [mean (95% CI)]: peak VO
conclusionIndividualized exercise interventions in low to moderate risk HCM patients were associated with improvements in functional capacity, exercise tolerance, cardiac adaptability, and chronotropic competence. The effect of beta-blockers on HRR and subsequent functional adaptations to training warrants future research. LIMITATIONS: Results should be interpreted cautiously due to heterogeneous study populations, predominantly mild/low-risk HCM phenotypes, the limited number of interventions, and restricted generalizability beyond individualized, guided, and mostly on-site supervised exercise settings. Trial registration The protocol was registered in PROSPERO: CRD420251058384. INFOGRAPHIC.
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