Evidence map›Paper›PMID 42455381›Full record

ReviewTopics in current chemistry (Cham)2026

Recent Progress in Coupling Reactions Involving the Novel Substrate of Bicyclo[1.1.0]butane (BCB).

Xiaoqing Li, Yu Xiang, Niannian Li, Lingling Deng, Mingming Zhang, Yang Ye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Topics in current chemistry (Cham), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoqing LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.
Yu XiangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.
Niannian LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.
Lingling DengSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.
Mingming ZhangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China. 20207053@hznu.edu.cn.
Yang YeSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China. yangye@hznu.edu.cn.

Funding

Health Commission of Zhejiang Province 2024KY237National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research 22401068
6 · The paper itself

Abstract

Bicyclo[1.1.0]butanes (BCBs) possess high ring strain and unique structural rigidity, making them versatile building blocks for constructing three-dimensional (3D) molecular frameworks. This review primarily focuses on the latest research advances in BCB since 2019, including cyclobutylation reaction, cyclization reaction, ring-opening reaction, and direct cross-coupling reaction. Mechanistic analysis centers on activation modes such as single-electron transfer, hydrogen atom transfer, and force-promoted cleavage, alongside selectivity control mechanisms including ligand-directed regional selectivity, chiral catalysis-mediated enantioselectivity, and minimization of dipole repulsion. Multiple systems have achieved highly efficient BCB functionalization and broad substrate compatibility.

Indexed as

Bridged Bicyclo CompoundsButanesCatalysisCyclizationMolecular StructureStereoisomerismBridged Bicyclo CompoundsButanesBCBCross-couplingCyclic compoundMulti-componentRadical

Identifiers

PMID42455381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.