ArticleMikrochimica acta2026
Non-enzymatic near-infrared up-conversion fluorescent microfluidic sensor integrated with smartphone platform for rapid sweat glucose detection.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intermittent and non-invasive glucose monitoring offers remarkable benefits for personalized diabetes management. We present a novel smartphone-integrated near-infrared (NIR) fluorescent microfluidic sensor for efficient sweat collection and fast, reliable detection of glucose. The microfluidic sensor contains four microchambers, each equipped with a bilayer membrane: the upper is sensing layer consisting of polyurethane matrix and non-enzymatic glucose probe PY-POFs, while the lower is light-converting layer consisting of PMMA matrix and up-conversion nanoparticles (UCNPs). Upon 808-nm NIR excitation, the light-converting layer excited the sensing layer via upconversion luminescence, and the glucose-sensitive fluorescence peaking at 470 nm is captured with a smartphone. The sensor exhibits a rapid response time of 15 s, excellent selectivity and stability due to the non-enzymatic nature, as well as a low detection limit of 20 µM because of low-background interference. Moreover, the practical applicability of our device is verified by tracking glucose fluctuations in sweat samples from human volunteers under pre- and post-prandial conditions, with results well correlated to those acquired by commercial blood glucose meters. The prototype demonstrated holds significant promise as a reliable, portable, and user-friendly sensing platform, suitable for rapid intermittent point-of-care non-invasive metabolic monitoring.
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