ReviewOphthalmology and therapy2026
Nonpenetrating Deep Sclerectomy versus Conventional Surgery in Primary Congenital Glaucoma: a Systematic Review and Meta-analysis.
Review in Ophthalmology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrimary congenital glaucoma (PCG) is a leading cause of irreversible childhood blindness, with elevated prevalence in consanguineous populations of the Middle East and Central Asia. Nonpenetrating deep sclerectomy (NPDS) is theoretically safer than conventional penetrating surgery, yet comparative evidence lacks systematic synthesis.
methodsWe systematically searched seven databases through December 2025. Eligible studies compared NPDS with conventional surgery in children with PCG aged under 4 years with ≥ 6 months follow-up. Two reviewers independently screened and extracted data; risk of bias was assessed with ROBINS-I and RoB 2.0. A random-effects meta-analysis [REML with Hartung-Knapp-Sidik-Jonkman (HKSJ) correction] was performed.
resultsFive studies [seven arms, 356 eyes; one randomized controlled trial (RCT), four observational] were included. Mean intraocular pressure (IOP) reduction was 10.34 mmHg (HKSJ 95% CI 7.54-13.14; 95% PI: 2.25-18.43 mmHg; I
conclusionsEvidence comparing NPDS and conventional surgery in PCG remains limited. Surgery achieved a mean IOP reduction of 10.34 mmHg (HKSJ 95% CI 7.54-13.14), though estimates showed substantial heterogeneity (I
trial registrationPROSPERO registration: CRD420251121650.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.