ArticleHistochemistry and cell biology2026
Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.
Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- July in focus in HCB: impact of environmental radiation on cells and tissues.Histochemistry and cell biology · 2026Article
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10 authors.
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Abstract
Chromatin contains genetic information in eukaryotes. Multiple epigenetic mechanisms, such as chemical modifications of DNA and histone post-translational modifications (PTMs), regulate chromatin organization and architecture, influencing RNA transcription and driving diverse gene expression patterns from the same genome. This epigenetic control is highly dynamic and influenced by various events, such as DNA insults which cause altered gene expressions to drive aging, neurodegeneration, and cancer. However, this interplay remains poorly understood and identifying novel molecular effectors may shed light for therapeutic purposes. Here, we investigate the consequences of UV exposure in cells expressing a mutant form of damage-specific DNA-binding protein 2 (DDB2), a key protein for UV damage repair, in which interaction with PCNA is disrupted, thereby impairing proper DDB2 degradation. Our data reports that overexpression of mutant DDB2 resulted in persistent epigenetic alterations after UV irradiation, which led to elevated detection of H3K9 acetylation and trimethylation, as well as increments in 5-methylcytosine and altered subnuclear localization of γ-H2AX. Collectively, these findings demonstrate that DDB2-PCNA interaction regulates not only DDB2 stability, but also the epigenetic landscape of the genome.
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