Evidence map›Paper›PMID 42455134›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Myeloid PKM2 deficiency alleviates allergic airway inflammation and promotes macrophage efferocytosis via SLC13A3.

Lingli Chen, Yile Liu, Yating Chen, Yue Zhang, Lei Yu, Yantong Zhu, Wang Peng, Maolan Wu, Xiangrong Zheng

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Lingli ChenDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Yile LiuThe Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Yating ChenDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Yue ZhangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Lei YuDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Yantong ZhuDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Wang PengThe Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Maolan WuNational Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, China.
Xiangrong ZhengDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China. xrzheng@csu.edu.cn.ORCID https://orcid.org/0000-0002-8616-0499

Funding

Hunan Provincial Natural Science Foundation of China 2025JJ90181National Natural Science Foundation of China 82170019
6 · The paper itself

Abstract

backgroundAllergic asthma is characterized by chronic airway inflammation that fails to resolve efficiently. Defective efferocytosis and metabolic reprogramming of macrophages are crucial factors in allergic diseases. While PKM2 is known to participate in phagocytosis and metabolism, its specific role in modulating asthma remains unclear.

objectiveTo delineate the underlying mechanisms of PKM2 in allergic asthma.

methodsWe generated myeloid cell-specific LysM

resultsWe found that PKM2 is upregulated in macrophages during asthma. Myeloid cell-specific PKM2 deficiency mitigated OVA-induced Th2 inflammation and eosinophilic apoptosis while reducing airway hyperresponsiveness (AHR). Mechanistically, PKM2-expressing macrophages exhibited decreased SLC13A3 transcription, which drove activation of the PI3K-AKT and redistributed STAT6/1 ratio to impair efferocytosis. This impairment disturbed the M2/M1 balance. In vitro experiments confirmed that SLC13A3 overexpression enhanced efferocytic capacity and promoted a shift toward M2/M1 balance. Conversely, PKM2 overexpression in macrophages impaired efferocytosis and exacerbated chronic airway inflammation.

conclusionOur study reveals a novel role for myeloid cell-specific PKM2 and SLC13A3 in asthma, linking efferocytosis to immune metabolism during allergic inflammation.

Indexed as

AsthmaCarrier ProteinsMacrophagesPyruvate KinaseThyroid HormonesAnimalsApoptosisCytokinesEfferocytosisFemaleHumansLungMiceMice, Inbred C57BLOvalbuminThyroid Hormone-Binding ProteinsCarrier ProteinsCytokinesOvalbuminPkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid HormonesAllergic inflammationEfferocytosisMacrophage polarizationPKM2SLC13A3

Identifiers

PMID42455134

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