Evidence map›Paper›PMID 42454942›Full record

ArticleMicrobiology spectrum2026

Rapid detection of treatment-emergent resistance to bedaquiline and pretomanid in

Senamile L Ngema, Saranathan Rajagopalan, Rubeshan Perumal, Sashen Moodley, Kevin J Guzman, Adrie J C Steyn, William R Jacobs, Kogieleum Naidoo, Max O'Donnell, Michelle H Larsen

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Senamile L NgemaCentre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0003-4355-5068
Saranathan RajagopalanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0003-2201-8028
Rubeshan PerumalCentre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
Sashen MoodleyAfrican Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Kevin J GuzmanDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Adrie J C SteynAfrican Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0001-9177-8827
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Kogieleum NaidooCentre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.
Max O'DonnellDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, New York, USA.
Michelle H LarsenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-3532-350X

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
Novel Reporter Phages to Detect Complex TB Drug Resistance and PersistenceR01AI114900 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Michelle H Larsen, Max O'Donnell · 2015 to 2026
$7.2M
Promoting Engagement in the Drug Resistant TB/HIV Care Continuum in South AfricaR01AI124413 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI O'DONNELL, MAX, PADAYATCHI, NESRI · 2016 to 2020
$2.7M
Nanoluciferase reporter phage for rapid phenotypic characterization of resistance to next-generation antimycobacterial agentsR21AI168940 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JACOBS, WILLIAM ROBERT, O'DONNELL, MAX · 2023 to 2024
$421k
National Research Foundation centre of excellence MND210624615487NIAID NIH HHS R01 AI114900NIAID NIH HHS R01 AI124413NIAID NIH HHS R21 AI168940NIAID NIH HHS R37 AI026170The European & Developing Countries Clinical Trials Partnership (EDCTP) Fellowships TMA2018SF-2467US National Institutes of Health R01AI114900US National Institutes of Health R21AI168940US National Institutes of Health R37AI026170
6 · The paper itself

Abstract

There is an urgent need for rapid, affordable diagnostic tools capable of detecting baseline and treatment-emergent resistance among patients with drug-resistant tuberculosis (DR-TB). Reporter mycobacteriophages provide a phenotypic solution enhanced by brighter luminescent reporters compatible with simple readouts. We applied the TM4:: IMPORTANCE: Ongoing transmission of drug-resistant tuberculosis (DR-TB), combined with limited access to rapid diagnostics for resistance to key drugs in modern regimens, poses a major challenge to global TB control. We applied TM4::

Indexed as

Antitubercular AgentsDiarylquinolinesMycobacteriophagesMycobacterium tuberculosisNitroimidazolesTuberculosis, Multidrug-ResistantGenes, ReporterHumansMicrobial Sensitivity TestsAntitubercular AgentsbedaquilineDiarylquinolinesNitroimidazolespretomanidbedaquilinedelamaniddrug susceptibility testingmycobacteriophagesMycobacterium tuberculosispretomanid

Identifiers

PMID42454942
PMCPMC13436348

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.