Evidence map›Paper›PMID 42454938›Full record

ArticlemSystems2026

A comprehensive study of intratumor bacteria in clear-cell renal cell carcinoma identifies

Yuqing Li, Dengwei Zhang, Linyi Tan, Junyao Xu, Yang Sun, Rui Zhang, Yao Cheng, Yong-Xin Li, Ting Guo, Haowen Jiang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuqing Li *Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0009-0001-2427-6445
Dengwei Zhang *Department of Chemistry and The Swire Institute of Marine Science, The University of Hong Kong, Hong Kong SAR, China.
Linyi TanDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Junyao XuState Key Laboratory of Oncogenes and Related Genes, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yang SunCancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Rui ZhangShanghai KR Pharmtech, Inc., Ltd, Shanghai, China.
Yao ChengShanghai KR Pharmtech, Inc., Ltd, Shanghai, China.
Yong-Xin LiDepartment of Chemistry and The Swire Institute of Marine Science, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-4422-2302
Ting GuoDepartment of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, China.ORCID 0000-0001-8861-328X
Haowen JiangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5349-1363
Wei ZhaiState Key Laboratory of Oncogenes and Related Genes, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-6274-6404
Chenchen FengDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-1854-356X

Funding

National Natural Science Foundation of China 82273248, 81874123
6 · The paper itself

Abstract

Intratumor bacteria (ITB) have emerged as key modulators in various malignancies; however, their role in clear-cell renal cell carcinoma (ccRCC) remains unclear and elusive. In this study, we analyzed seven independent cohorts (comprising one 16S rRNA sequencing and six bulk RNA sequencing data sets) encompassing 517 ccRCC and 65 paired adjacent normal tissues. Following a rigorous decontamination pipeline, we found that neither microbial diversity nor compositional profiles differed significantly between cancerous and adjacent normal tissues. Thirteen specific genera-including IMPORTANCE: To address previous methodological limitations, we applied rigorous decontamination to multi-omic datasets to isolate and experimentally validate intratumor bacteria colonization in ccRCC. Comparable profiles between tumorous and normal tissues suggest intratumor bacteria generally act as "passengers." We successfully constructed robust microbial risk scores predictive of patient survival. Mechanistically,

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMacrophagesPropionibacteriaceaeFemaleHumansMalePrognosisRNA, Ribosomal, 16STumor MicroenvironmentRNA, Ribosomal, 16Sclear-cell renal cell carcinomaCutibacterium acnesintratumor bacteriamacrophage polarizationprognosis

Identifiers

PMID42454938
PMCPMC13483239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.