ArticlemBio2026
Spatiotemporal compartmentalization of NADPH oxidase signaling coordinates cell fusion and predatory behavior in nematode-trapping fungi.
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Reactive oxygen species (ROS) act both as cytotoxic agents and essential signaling molecules. In the nematode-trapping fungus IMPORTANCE: Reactive oxygen species (ROS) are not only toxic byproducts of mitochondrial activity but also important signaling molecules in eukaryotes. To fulfill this signaling role, ROS production must be tightly regulated. NADPH oxidases are key contributors to controlled ROS generation, as they may be regulated at the transcriptional level, targeted to specific cellular locations, and activated by dedicated regulatory proteins. Here, we investigated the role of NADPH oxidases in the nematode-trapping fungus Arthrobotrys flagrans and show that two NADPH oxidases serve distinct roles: one is required for trap function, while the other mediates cell-to-cell communication and is required for hyphal fusion and trap closure. The latter finding suggests ROS, most likely H₂O₂, as a diffusible signaling molecule between communicating fungal cells.
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