Evidence map›Paper›PMID 42454931›Full record

ArticleMicrobiology spectrum2026

Exploring SNPs in viral entry-related protein genes and their association with severe fever with thrombocytopenia syndrome virus infection risk.

Min Wang, Chengrui Ren, Guoqiang Deng, Yan Shen, Peng Cheng, Liqin Qian, Yong Qi, Weilong Tan, Yinchu Chai, Yuting Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Min Wang *Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chengrui Ren *Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Guoqiang Deng *General Office, Huangshan Center for Disease Control and Prevention, Huangshan, China.
Yan ShenDepartment of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Peng ChengClinical Laboratory, Huangshan Center for Disease Control and Prevention, Huangshan, China.
Liqin Qian
Yong QiDepartment of Infectious Disease Prevention and Control, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China.ORCID 0000-0001-6186-9023
Weilong TanDepartment of Infectious Disease Prevention and Control, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China.
Yinchu ChaiResearch and Production Center, Nanjing Shengxing Pest Control Technology Co., Ltd, Nanjing, China.
Yuting ChenKey Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Tian ZengDepartment of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wen YinKey Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Chuanlong ZhuDepartment of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Ming YueDepartment of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.ORCID 0000-0002-7677-0832

Funding

Jiangsu Provincial Natural Science Foundation Social Development Project BE2022682Natural Science Foundation of Jiangsu Province 20241748Natural Science Foundation of Jiangsu Province BK20241748State Key Laboratory for Biosafety of Pathogenic Microorganisms SKLPBS2137the Key Project of the Science and Technology Program of Jiangsu Provincial Center for Disease Control and Prevention JSJK2026Z00002the State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV), also known as Dabie bandavirus, is the pathogen causing severe fever with thrombocytopenia syndrome (SFTS). Human cell receptors are the first barriers to viral entry, proliferation, and host immune response. This study explored the association between single nucleotide polymorphisms (SNPs) in genes encoding receptors or related molecules that mediate SFTSV cell entry, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), DC-SIGN-related protein (DC-SIGNR), and non-muscle myosin heavy chain IIA (NMMHC-IIA), and SFTSV infection susceptibility in the Chinese Han population, as well as the underlying potential biological mechanisms. From September 2020 to December 2022, 454 subjects from the First Affiliated Hospital with Nanjing Medical University were enrolled and divided into SFTSV-infected and uninfected groups based on SFTSV RNA and antibody test results. TaqMan SNP genotyping was performed on

Indexed as

Cell Adhesion MoleculesLectins, C-TypePhlebovirusPolymorphism, Single NucleotideReceptors, Cell SurfaceSevere Fever with Thrombocytopenia SyndromeVirus InternalizationAdultChinaDC-Specific ICAM-3 Grabbing NonintegrinFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedCell Adhesion MoleculesCLEC4M protein, humanDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeMYH9 protein, humanMyosin Heavy ChainsReceptors, Cell Surfacecell receptorsDC-SIGNDC-SIGNRNMMHC-IIAsevere fever with thrombocytopenia syndromesevere fever with thrombocytopenia syndrome virussingle nucleotide polymorphisms

Identifiers

PMID42454931
PMCPMC13436344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.