Evidence map›Paper›PMID 42454929›Full record

Trial reportmSphere2026

Effects of improved water, sanitation, handwashing, and nutrition on early childhood IgG immune repertoire development against

Nikolina Walas, Everlyn Kamau, Minlu Zhang, Kathy Kamath, Jack Reifert, John Shon, Shahjahan Ali, Md Ziaur Rahman, Abul K Shoab, Syeda L Famida and 14 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Nikolina WalasSchool of Public Health, University of California, Berkeley, California, USA.ORCID 0000-0002-6137-9275
Everlyn KamauFrancis I. Proctor Foundation, University of California, San Francisco, California, USA.
Minlu ZhangSerimmune Inc., Goleta, California, USA.
Kathy KamathSerimmune Inc., Goleta, California, USA.
Jack ReifertSerimmune Inc., Goleta, California, USA.
John ShonSerimmune Inc., Goleta, California, USA.
Shahjahan AliInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Ziaur RahmanInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Abul K ShoabInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Syeda L FamidaInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Salma AktherInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Md Saheen HossenInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Palash MutsuddiInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Mahbubur RahmanInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0003-1181-6817
Jessica A GrembiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Andrew N MertensDivision of Epidemiology, University of California Berkeley, Berkeley, California, USA.
Taufiqur R BhuiyanInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0003-3755-4763
Firdausi QadriInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.ORCID 0000-0002-8928-9888
Edward T RyanMassachusetts General Hospital Harvard Medical School, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0009-0005-0169-394X
Richelle C CharlesMassachusetts General Hospital Harvard Medical School, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-8881-1849
Daniel LeungDivision of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-8401-0801
Stephen LubyDivision of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
Audrie LinDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA.
Benjamin F ArnoldFrancis I. Proctor Foundation, University of California, San Francisco, California, USA.

Funding

Functional profiling of OSP-specific and other antibodies during shigella infectionR01AI155414 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Edward T. Ryan · 2020 to 2026
$5.3M
Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settingsR01AI166671 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Benjamin F Arnold · 2022 to 2026
$2.7M
Bill and Melinda Gates Foundation OPPGD759NIAID NIH HHS R01 AI155414NIAID NIH HHS R01 AI166671NIH HHS R01AI155414
6 · The paper itself

Abstract

We studied the effects of a combined water, sanitation, handwashing, and nutritional supplementation (WSH + N) intervention on

Indexed as

Antibodies, BacterialDysentery, BacillaryEscherichia coli InfectionsHand DisinfectionImmunoglobulin GSanitationShigellaBangladeshChild, PreschoolEscherichia coliFemaleHumansInfantMaleSeroepidemiologic StudiesAntibodies, BacterialImmunoglobulin Gimmune repertoireserologyshigellaWASH

Identifiers

PMID42454929
PMCPMC13508797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.