Evidence map›Paper›PMID 42454897›Full record

ArticleOperative neurosurgery (Hagerstown, Md.)2026

Using Multinodal Deep Brain Stimulation for Treatment of Complex Movement Disorders: Initial Case Series.

Benjamin C Sherman, Mahad A Ahmed, Lior Lev-Tov, David A Purger, Brandon Reid, Traci Hornbeck, Jessica R Verhein, Casey H Halpern, Maya Katz, Jaimie M Henderson and 2 more

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Article in Operative neurosurgery (Hagerstown, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Benjamin C ShermanDepartment of Neurosurgery, Geisinger Health System, Danville , Pennsylvania, USA.ORCID 0000-0002-2235-4323
Mahad A AhmedDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.
Lior Lev-TovDepartment of Neurosurgery, Rambam Health Care Campus, Haifa , Israel.
David A PurgerDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.
Brandon ReidDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.
Traci HornbeckDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.
Jessica R VerheinDepartment of Psychiatry, University of California San Francisco, San Francisco , California , USA.
Casey H HalpernDepartment of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia , Pennsylvania , USA.
Maya KatzDepartment of Neurology, Stanford University School of Medicine, Stanford , California , USA.
Jaimie M HendersonDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.
Margaret FerrisDepartment of Neurology, Stanford University School of Medicine, Stanford , California , USA.
Vivek P BuchDepartment of Neurosurgery, Stanford University School of Medicine, Stanford , California , USA.ORCID 0000-0003-1151-6128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMixed and complex movement disorders represent significant challenges for surgical treatment. These disease states are likely the result of combined or complex network pathologies affecting multiple pathways. Until recently, attempts to treat complex movement disorders with deep brain stimulation (DBS) have primarily focused on stimulating a single deep target to address patients' most severe symptoms. However, a multinodal targeting approach for DBS by simultaneously stimulating more than 1 pair of homologous nuclei could be a more effective treatment strategy. In this study, we present the initial case series of using multinodal stimulation for mixed and complex movement disorders.

methodsA cohort of 14 patients with mixed and complex movement disorder presenting to Stanford Healthcare underwent a multinodal stimulation approach. In these patients, the multiple (ie, >2) simultaneous deep targets were implanted through only 2 burr holes and connected to a single 32-channel pulse generator. Six patients had previous single target DBS which had proved ineffective, whereas 9 received de novo multinodal therapy.

resultsThere were no intraoperative or postoperative complications. With the addition of multinodal stimulation, patients with complex Parkinson disease demonstrated a significant reduction in Unified Parkinson Disease Rating Scale (P = .0078) and complex tremor patients demonstrated a significant reduction in Clinical Rating Scale for Tremor (P = .0312).

conclusionWe present the largest initial case series demonstrating the safety, feasibility, and added efficacy of single system multinodal DBS for treating mixed and complex movement disorders. This approach is safe, provides additional benefit, and warrants further investigation for treating mixed and complex movement disorders.

Indexed as

Deep Brain StimulationMovement DisordersParkinson DiseaseAdultAgedFemaleHumansMaleMiddle AgedTreatment OutcomeDeep brain stimulationDystoniaEssential tremorFunctional neurosurgeryHolmes tremorMovement disordersParkinson disease

Identifiers

PMID42454897
PMCPMC13348831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.