Observational studyCoDAS2026
Sensitivity, specificity, and cutoff points of the Cough Severity Index (CSI-Br) and the Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ-Br) in individuals with chronic refractory cough.
Observational study in CoDAS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
purposeTo establish cutoff points and evaluate the discriminative accuracy of the self-perception instruments Cough Severity Index (CSI-Br) and Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ-Br) in identifying symptoms related to chronic refractory cough (CRC) in adults.
methodsThis is a cross-sectional, observational, quantitative study with a sample of 157 participants (111 females and 46 males), with a mean age of 44.92 years. They were divided into two groups based on the presence or absence of CRC: Group with CRC (CRC-G) with 110 participants (31 males and 79 females), with a mean age of 48.67 (SD: 16.04) years; The study included a healthy control group (CG) with 47 participants (15 males and 32 females), with a mean age of 36.34 (SD: 14.31) years. Data were collected in person at the outpatient clinics of the participating hospitals and online via Google Forms. Participants answered the CSI-Br and LHQ-Br. Analysis was performed using SPSS 29.0 software, employing ROC curves to determine cutoffs and performance metrics.
resultsFor the LHQ-Br, the area under the curve (AUC) was 0.753, with a cutoff of 5.8, sensitivity of 70%, and specificity of 73.4%. The CSI-Br had an AUC of 0.894 in the total score, with a cutoff of 4.5, sensitivity of 84.9%, and specificity of 83%.
conclusionBased on the established cutoffs, both questionnaires proved to be sensitive and specific, with greater robustness for CSI-Br.
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