Observational studyRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2026
Newborn screening versus clinical diagnosis: comparison of nutritional status in children with cystic fibrosis - a longitudinal study.
Observational study in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to compare the nutritional status of individuals with cystic fibrosis (CF) diagnosed either through newborn screening (NBS) or based on clinical findings (early vs. late), at the time of diagnosis and 1 year later.
methodsThis was an observational study including CF patients followed at a Referral Center from 2005 to 2023. Participants were classified into three subgroups according to the method and age at diagnosis: 1 (NBS); 2 (early signs and symptoms if the CF diagnosis was before 2 years of age); and 3 (late signs and symptoms if the CF diagnosis was after 2 years of age). Nutritional parameters were compared at diagnosis and 1 year after treatment.
resultsA total of 63 individuals were included, 57.1% male, 81.0% non-white, and median (interquartile range) age at diagnosis of 6 (2-42) months. There were 21, 23, and 19 in subgroups 1, 2, and 3, respectively. At diagnosis, 26 (41.3%) individuals had short stature (SST) or very SST, corresponding to 57.1, 43.5, and 21.1% of children in subgroups 1, 2, and 3, respectively. After 1 year, these proportions decreased to 28.5 and 30.4% in subgroups 1 and 2, while remaining unchanged in subgroup 3. Pancreatic insufficiency was present in 85.7, 69.6, and 68.4% of participants in subgroups 1, 2, and 3, respectively.
conclusionsShort stature was frequent at diagnosis, even among children identified by NBS. After 1 year of follow-up, height improved in subgroups 1 and 2 but remained unchanged in subgroup 3. Early diagnosis and timely nutritional interventions are essential to prevent and correct growth deficits in individuals with CF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.