Evidence map›Paper›PMID 42454784›Full record

ArticleGut microbes2026

Dietary intervention through bacterial-derived butyrate elicits anti-tumor activity and increases anti-PD-1 response.

Myriam Benlaïfaoui, Corentin Richard, Sébastien Hunter, Eder Orlando Méndez-Salazar, Sylva Kourtian, Julie Malo, Diogjena Katerina Prifti, Mayra Ponce, Soumia Khalfi, Wiam Belkaïd and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Myriam BenlaïfaouiCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Corentin RichardCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Sébastien HunterCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Eder Orlando Méndez-SalazarCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Sylva KourtianCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Julie MaloCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Diogjena Katerina PriftiCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Mayra PonceCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Soumia KhalfiCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Wiam BelkaïdCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Meriem MessaoudeneCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Romain BoidotUniversité Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, Unité de Biologie Moléculaire, ICMUB UMR CNRS 6302, Dijon, France.
Caroline TruntzerUniversité Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, Cancer Biology Transfer Platform, INSERM, CTM UMR 1231, TIRECs Team, Dijon, France.
François GirhinghelliUniversité Bourgogne Europe, Centre Georges-François Leclerc, Unicancer, Cancer Biology Transfer Platform, INSERM, CTM UMR 1231, TIRECs Team, Dijon, France.
Catherine Lehoux-DuboixDépartement de Nutrition, Faculté de Médecine, Université de Montréal, Montreal, Québec, Canada.
Petronela AncutaCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Arielle ElkriefCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.
Valérie MarcilDépartement de Nutrition, Faculté de Médecine, Université de Montréal, Montreal, Québec, Canada.
Bertrand RoutyCentre de Recherche du Centre Hospitalier de Montréal (CRCHUM), Montréal, Québec, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome is increasingly recognized as a key modulator of cancer immunotherapy efficacy. Given that diet is one of the most important determinants of the gut microbiome composition and function, nutritional strategies have emerged as promising tools to modulate anti-tumor immune responses. Here, we demonstrate that dietary supplementation with inulin reduces tumor growth and enhances

Indexed as

BacteriaButyratesCarcinoma, Non-Small-Cell LungGastrointestinal MicrobiomeLung NeoplasmsProgrammed Cell Death 1 ReceptorAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDietary FiberDietary SupplementsFatty Acids, VolatileFemaleHumansInulinMiceButyratesDietary FiberFatty Acids, VolatileInulinProgrammed Cell Death 1 ReceptorbutyratecancerDietary fibergut microbiomeimmunotherapyNSCLCSCFA

Identifiers

PMID42454784
PMCPMC13374751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.