Evidence map›Paper›PMID 42454700›Full record

ArticleCNS neuroscience & therapeutics2026

Mechanical Ventilation-Associated Changes in Hippocampal Electroencephalogram: A Cross-Species Study in Humans and Rats.

Xiang Qi, Xiaoyu Ou, Jingyi Li, Meizhizi Zhang, Fenqin Xue, Hua Wei, Wenting Su, Jing Wang, Yongxing Sun, Jian Zhou and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06480162 (Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06480162 unknown statusnot on this map

Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling

TypeobservationalSponsorBeijing Sanbo Brain HospitalRan2024 to 2025Enrolled20ConditionsMechanical Ventilation Complication, Brain InjuriesArmsMechanical ventilation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiang QiDepartment of Neurosurgery, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Xiaoyu OuBeijing Key Laboratory of Traffic Data Mining and Embodied Intelligence, School of Computer Science and Technology, Beijing Jiaotong University, Beijing, China.
Jingyi LiLaboratory for Clinical Medicine, Capital Medical University, Beijing, China.
Meizhizi ZhangLaboratory for Clinical Medicine, Capital Medical University, Beijing, China.
Fenqin XueLaboratory of in Vivo Electrophysiology, Core Facility Center of Capital Medical University, Beijing, China.
Hua WeiLaboratory of in Vivo Electrophysiology, Core Facility Center of Capital Medical University, Beijing, China.
Wenting SuLaboratory for Clinical Medicine, Capital Medical University, Beijing, China.
Jing WangBeijing Key Laboratory of Traffic Data Mining and Embodied Intelligence, School of Computer Science and Technology, Beijing Jiaotong University, Beijing, China.
Yongxing SunDepartment of Neurosurgery, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Jian ZhouEpilepsy Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Baoguo WangDepartment of Neurosurgery, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-8299-283X
Zhonghua ShiLaboratory for Clinical Medicine, Capital Medical University, Beijing, China.

Funding

Excellent Young Talents Project of Capital Medical University A2308
6 · The paper itself

Abstract

aimsTo identify hippocampal intracranial electroencephalography (iEEG) signatures associated with mechanical ventilation (MV) in humans and rats and assess their translational relevance.

methodsHippocampal iEEG was recorded in humans (n = 9) and rats (n = 12; MV + propofol vs. propofol-only, n = 6 per group). Power spectral density (PSD), spectral exponent (SE), and trajectory entropy (TE) were quantified to characterize MV-related neural changes.

resultsMV was associated with consistent directional hippocampal iEEG changes across species, with increased PSD, SE, and reduced TE. In humans, PSD increases were mainly posterior (delta-alpha; p < 0.05), while in rats they spanned dorsal theta-gamma (p < 0.05). SE increased in humans (38.5%, p < 0.001) and rats (26.6%, p < 0.01), while TE decreased in humans (11.2%, p < 0.001) and rats (6.9%, p = 0.001). Cross-species differences were greater in the posterior/dorsal hippocampus (PSD: d = -0.924 [-1.521 to -0.328]; SE: d = 0.944 [0.346 to 1.542]) than in anterior/ventral regions. In rats, MV increased low-frequency power and SE and reduced dorsal TE under propofol.

conclusionsMV is associated with comparable hippocampal iEEG changes across species, supporting the rat model for MV-related neural dynamics. Nevertheless, the findings are EEG-restricted and lack general translational validity for brain injury. CLINICAL TRAIL REGISTRATION: ClinicalTrails.gov (NCT06480162; Zhonghua Shi; May 8, 2024).

Indexed as

ElectroencephalographyHippocampusRespiration, ArtificialAdultAnimalsFemaleHumansMaleObservational Studies as TopicPropofolRatsRats, Sprague-DawleySpecies SpecificityYoung AdultPropofolcross‐species comparisonhumanintracranial electroencephalogrammechanical ventilationratventilator‐associated brain injury

Identifiers

PMID42454700
PMCPMC13371090

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.