ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Constructing a NIR AIEgen Based on the Novel Molecular Framework for Imaging Lipid Droplet Accumulation in Parkinson's Disease Mouse Brain.
Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's disease (PD) pathogenesis has been linked to the aberrant accumulation of lipid droplets (LDs). Understanding the situation of LD accumulation and its dynamic variations in the neural tissues of PD patients is therefore crucial for deciphering the underlying pathophysiological mechanisms of this neurodegenerative disorder. Developing a specific fluorescent probe for LDs that can also function within the brain presents a significant challenge. This study introduces a NIR (near-infrared) emitting fluorescent probe, QCN-TP, through step-by-step molecular design strategy, based on a novel framework of dye, characterized by multiple advantageous properties, including polarity sensitivity, a substantial Stokes shift (150-280 nm), and aggregation-induced emission (AIE). The probe, QCN-TP, demonstrates remarkable sensitivity and selectivity in the recognition of LD accumulation, with enhanced deep tissue penetration capabilities. Notably, QCN-TP effectively monitors both the presence of intracellular LDs and their dynamic content variations in MPP
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