Evidence map›Paper›PMID 42454309›Full record

ArticleFrontiers in public health2026

The association between blood lipid levels and the risk of atrophic gastritis: a cross-sectional study of the Wuwei cohort.

Bowen Li, Jie Gao, Ya Zheng, Linzhi Lu, Rui Ji, Qinghong Guo, Zhaofeng Chen, Yuping Wang, Hong Lu, Qian Ren and 1 more

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Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Bowen Li *The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Jie Gao *The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Ya Zheng *The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Linzhi Lu *Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China.
Rui JiThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Qinghong GuoThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Zhaofeng ChenThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Yuping WangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Hong LuThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Qian RenThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Yongning ZhouThe First School of Clinical Medicine, Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aberrant lipid profiles have been associated with several chronic diseases; however, their relationship with atrophic gastritis remains unclear. This study aimed to examine the association between serum lipid levels and the prevalence of chronic atrophic gastritis among participants from the Wuwei cohort. Methods: We conducted a cross-sectional analysis of 5,194 participants from the Wuwei cohort, including individuals with pathologically confirmed chronic atrophic gastritis and individuals with normal gastric mucosa. Serum lipid parameters, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, were assessed. Odds ratios and 95% confidence intervals for prevalent chronic atrophic gastritis were estimated using binary logistic regression models. Results: In Model 1, elevated total cholesterol was identified as a risk factor for the development of chronic atrophic gastritis (CAG) with an odds ratio (OR) of 1.07 (95% CI = 1.01-1.14). Similarly, elevated LDL was associated with an increased risk of atrophic gastritis, with an OR of 1.20 (95% CI = 1.10-1.32) compared to the group without CAG. These associations remained significant in Model 2, with odds ratios of 1.10 (95% CI = 1.03-1.17) for total cholesterol and 1.21 (95% CI = 1.10-1.34) for LDL. Conclusion: In this cross-sectional study, higher total cholesterol and LDL cholesterol levels were associated with greater odds of prevalent chronic atrophic gastritis.

Indexed as

Gastritis, AtrophicLipidsAdultChinaCholesterolCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsCholesterolLipidsatrophic gastritisblood lipidcholesterolcross-sectional studyHelicobacter pyloriLDL cholesterol

Identifiers

PMID42454309
PMCPMC13365318

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