ArticleCellular and molecular bioengineering2026
Decoupling Mechanical Confinement and Fibrotic Extracellular Matrix Signaling in Vestibular Schwannoma Using Tunable 3D Hydrogels.
Article in Cellular and molecular bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Vestibular schwannoma (VS) progressively stiffens and remodels its extracellular matrix (ECM) during growth. However, how mechanical confinement and adhesive ECM signaling regulate schwannoma behavior Methods: Human Nf2 Results: Under non-adhesive confinement, increasing stiffness suppressed schwannoma reduced cell spreading, decreased N-cadherin expression, and increased nuclear YAP localization. Stress relief reversed YAP activation while enabling enhanced proliferative recovery and increased N-cadherin-associated adhesion. Cells under increased confinement exhibited increased sensitivity to YAP inhibition, indicating confinement-dependent reliance on mechanotransduction. In contrast, adhesive ECM conditions supported active matrix remodeling with increasing stiffness, including elevated activities of MMP9 and phosphorylated focal adhesion kinase (pFAK). TGF-β induced both collagen disorganization and SMAD3 nuclear localization, which was attenuated by YAP inhibition. Conclusions: Mechanical confinement and ECM composition drive distinct, context-dependent adaptation programs in VS. As stiffness increases, cells in non-adhesive environments adopt a reversible, YAP-associated stress response, while an adhesive ECM shifts behavior toward matrix remodeling and cell adhesion-driven signaling. Supplementary Information: The online version contains supplementary material available at 10.1007/s12195-026-00911-3.
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