ArticleCellular and molecular bioengineering2026
The Role of Platelet-Derived Microparticles in Platelet Adhesion and Aggregation to Immobilized Extracellular Matrix Proteins Under Flow.
Article in Cellular and molecular bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Introduction: Platelet adhesion and aggregation on exposed vascular extracellular matrix (ECM) is critical for haemostasis, with dysregulation and inappropriate thrombus formation associated with cardiovascular disease. While collagen is recognised as vital in these processes, the role of other ECM proteins is less understood. Platelet-derived microparticles (PDMPs), small vesicles released by activated platelets, similarly influence haemostasis, though their modulatory effect on ECM substrates is also unclear. We investigated platelet adhesion and aggregation on various ECM proteins-collagen, fibrinogen, fibronectin, and laminin-and examined the modulatory role of PDMPs under physiologic and pathologic flow conditions. Methods: Whole blood, alone or enriched with PDMPs, was perfused through microfluidic channels coated with ECM substrates at varying shear rates. Fluorescence imaging assessed platelet behaviour measuring surface coverage, number of thrombi, mean thrombus area and thrombus height. Results: Collagen exhibited greatest overall thrombus formation, versus the other ECM substrates, with platelet adhesion and aggregation increasing at higher shear rates. Addition of PDMPs significantly reduced thrombus area ( Conclusion: Collagen exerts a dominant effect in platelet adhesion and aggregation across a wide range of shear, compared to fibrinogen, fibronectin and laminin. PDMPs alter platelet adhesion and resultant thrombus formation across all ECM proteins tested, likely through competitive occupation of platelet binding sites. Our findings underscore the complex interactions between ECM proteins, PDMPs, and shear forces under flow conditions. Supplementary Information: The online version contains supplementary material available at 10.1007/s12195-026-00920-2.
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