Evidence map›Paper›PMID 42454194›Full record

ReviewExtracellular vesicles and circulating nucleic acids2026

Uncovering the dynamics of extracellular vesicle microRNA trafficking in multiple sclerosis: delivery, diversion and retention.

Gemma C Stevenson, Manisha S Patil, Georges E R Grau

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gemma C StevensonVascular Immunology Unit, Infection, Immunity & Inflammation Theme, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.
Manisha S PatilVascular Immunology Unit, Infection, Immunity & Inflammation Theme, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.
Georges E R GrauVascular Immunology Unit, Infection, Immunity & Inflammation Theme, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are phospholipid-bound structures that carry a distinct repertoire of short, non-coding microRNAs (miRNAs). EV miRNA content differs across various diseases, including multiple sclerosis (MS). These observations may indicate a functional role for EV miRNAs in disease pathology. However, the role of EVs in miRNA trafficking remains a subject of debate. This review proposes a theoretical framework to understand the dynamics of EV miRNA trafficking in MS. Three modes of EV miRNA trafficking are presented: (i) delivery of miRNA to target cells; (ii) diversion of miRNA away from its target; or (iii) retention of the miRNA in the parent cell. This model accounts for the heterogeneity and functional diversity of EVs and may facilitate the identification of physicochemically distinct subpopulations with selective roles in miRNA transfer.

Indexed as

cytokinesexosomesExtracellular vesiclesimmunopathologymicrovesiclesmiRNAmultiple sclerosis

Identifiers

PMID42454194
PMCPMC13367149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.