ArticleFrontiers in medicine2026
Dynamic perioperative inflammatory biomarkers predict intrauterine adhesion formation following hysteroscopic myomectomy: a prospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intrauterine adhesions (IUAs) are a common complication following hysteroscopic submucosal myomectomy and are closely linked to impaired endometrial healing. The role of perioperative inflammatory biomarkers in predicting adhesion formation remains incompletely defined. Methods: This prospective cohort study included 140 women undergoing hysteroscopic submucosal myomectomy at a tertiary care center between April 2024 and October 2025. Serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF- Results: IUAs developed in 42 patients (30.0%). Baseline characteristics were comparable between groups; however, FIGO type II fibroids and longer operative time were significantly associated with adhesion formation ( Conclusion: Perioperative inflammatory response, particularly elevated IL-6 and CRP levels, is strongly associated with intrauterine adhesion formation following hysteroscopic myomectomy. Early postoperative biomarker assessment may provide a valuable strategy for risk stratification and targeted prevention of IUAs.
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