Evidence map›Paper›PMID 42454108›Full record

ArticleFrontiers in medicine2026

A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range.

Run Zhao, Linlin Che, Xiao Li, Xiaofang Li, Qianyan Song

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Run ZhaoDepartment of Reproductive Medicine, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
Linlin CheDepartment of Reproductive Medicine, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
Xiao LiDepartment of Reproductive Medicine, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
Xiaofang LiDepartment of Reproductive Medicine, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
Qianyan SongDepartment of Reproductive Medicine, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The study investigates the impact of gonadotropin (Gn) dose on embryo quality and pregnancy outcome in patients receiving controlled ovarian stimulation (COS) with antagonist regimen fertility treatment to identify the optimal dose range of Gn. Methods: In total, 1854 patients treated for Results: The rates of excellent embryos, single blastocyst transfer, clinical pregnancy, and live births were significantly higher and abortion rates were significantly lower for group 1 than for groups 2, 3, and 4. The rates of blastocyst formation were higher in groups 1 and 2 than in groups 3 and 4. Regression analysis showed that total Gn was an independent risk factor for rates of positive human chorionic gonadotropin (HCG), abortion, and live birth and was negatively correlated with blastocyst formation rate ( Conclusion: Gn dose influences embryo quality and pregnancy outcome during COS. Adjustment of Gn dose may improve IVF outcomes.

Indexed as

antagonist regimenembryo conditiongonadotropin dosepregnancy outcomerestricted cubic spline curve

Identifiers

PMID42454108
PMCPMC13365333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.