Evidence map›Paper›PMID 42454062›Full record

ArticleFrontiers in immunology2026

Iron overload disrupts bone homeostasis via TfR1-dependent ferroptosis and cGAS/STING-driven pyroptosis in pyogenic spondylitis.

Wenchao Xu, Qinpeng Xu, Hongdong Tan, Xiaodong Liu, Jiaju Ma, Fei Jia, Heng Yang, Meimei Zheng, Jianlong Li, Xingang Cui and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenchao Xu *Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Qinpeng Xu *Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Hongdong Tan *Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
Xiaodong Liu *Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Jiaju MaDepartment of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Fei JiaDepartment of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Heng YangDepartment of Spine Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Meimei ZhengDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Jianlong LiShandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
Xingang CuiDepartment of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Xingzhi JingDepartment of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Xiaoyang LiuDepartment of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pyogenic spondylitis (PS) accompanies with diverse destruction, especially the subsequent bone destruction, which leads to spine instability and severe neurological disability. However, the mechanism underlying bone loss induced by infection has not been elucidated. In this study, we aimed to reveal a novel mechanism of bone destruction in PS. Methods: To certify the involvement of iron overload in PS-induced bone loss, vertebrae samples were collected and evaluated from patients with PS. Next Results: Infected vertebral specimens from PS patients showed iron overload and increased TfR1 expression, which was also observed in Conclusions: Our research indicates that

Indexed as

Antigens, CDBone and BonesIron OverloadMembrane ProteinsNucleotidyltransferasesPyroptosisReceptors, TransferrinSpondylitisStaphylococcal InfectionsAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHomeostasisHumansMaleAntigens, CDCD71 antigenCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesReceptors, TransferrinSTING Proteinbone losscGAS/STING pathwayiron overloadosteoblastosteoclastoxidate stresspyogenic spondylitisTFR1

Identifiers

PMID42454062
PMCPMC13364566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.