ArticleFrontiers in immunology2026
Case Report: A case of primary IgG4-related skin disease presenting initially with skin papules and abscesses.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immunoglobulin G (IgG) type 4-related disease (IgG4-RD) is a rare, chronic fibroinflammatory condition that can affect multiple organ systems. Cutaneous involvement in IgG4-RD is even rarer. Moreover, the clinical manifestations of primary IgG4-related skin disease (IgG4-RSD) are often atypical, making it easy for clinicians to misdiagnose or overlook the condition, leading to delays in diagnosis and treatment. Conclusion: Primary IgG4-RSD is rare and diagnostically challenging, as it can mimic a wide range of diseases and its pathogenesis remains incompletely understood. A definitive diagnosis requires markedly elevated serum IgG levels, characteristic histopathological findings, and rigorous exclusion of mimicking disorders. Additionally, the condition tends to relapse during treatment. Therefore, enhancing clinicians' understanding of IgG4-RD is crucial.
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