Evidence map›Paper›PMID 42453961›Full record

ArticleRSC advances2026

Mutagenesis and free energy calculations to optimize the ProRgpB inhibitor loop and identify variants with higher affinity for

Sebastián Tapia, Osvaldo Yañez, Olimpo García-Beltrán, Daniel Bustos, Denisse Bravo, Manuel I Osorio

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sebastián TapiaComputational & Quantum Enzyme Modeling Lab. Facultad de Odontología, Universidad Andres Bello Santiago, Chile, Echaurren 237 Santiago 8370133 Chile manuel.osorio@unab.cl.
Osvaldo YañezCentro de Modelación Ambiental y Dinámica de Sistemas (CEMADIS), Facultad de Ingeniería y Negocios, Universidad de Las Américas Santiago Chile.ORCID https://orcid.org/0000-0001-8993-9353
Olimpo García-BeltránCo-Laboratorio de Investigación en Bioeconomía Regional, Universidad de Ibagué Carrera 22 Calle 67 Ibagué 730002 Colombia.ORCID https://orcid.org/0000-0003-3312-1776
Daniel BustosLaboratorio de Bioinformática y Química Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica Del Maule Talca 3480094 Chile dbustos@ucm.cl.ORCID https://orcid.org/0000-0002-2136-2305
Denisse BravoComputational & Quantum Enzyme Modeling Lab. Facultad de Odontología, Universidad Andres Bello Santiago, Chile, Echaurren 237 Santiago 8370133 Chile manuel.osorio@unab.cl.ORCID https://orcid.org/0000-0002-5749-4086
Manuel I OsorioComputational & Quantum Enzyme Modeling Lab. Facultad de Odontología, Universidad Andres Bello Santiago, Chile, Echaurren 237 Santiago 8370133 Chile manuel.osorio@unab.cl.ORCID https://orcid.org/0000-0002-1297-8351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arginine-specific gingipain B (RgpB), a key cysteine protease from

Identifiers

PMID42453961
PMCPMC13366090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.