Trial reportDrug design, development and therapy2026
Induction of General Anesthesia with Fospropofol in Elderly Patients Undergoing Hip Surgery: An Efficacy and Safety Analysis.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Purpose: To compare fospropofol with etomidate for the induction of anesthesia in elderly patients undergoing hip surgery, with a focus on safety and efficacy. Patients and Methods: A prospective, single-blind, randomized, controlled study that enrolled 120 elderly patients, who were randomly assigned to a fospropofol group (10 mg/kg, group P, n = 60) or an etomidate group (0.3 mg/kg, group E, n = 60). The main outcome was the time to loss of consciousness (LOC). The secondary endpoints were the success rate of anesthesia induction, hemodynamic parameters, adverse reactions, dosage of anesthetic maintenance drugs and postoperative recovery conditions. Results: The study was completed by all enrolled patients in both groups. The success rate for induction of general anesthesia in both groups was 100% ( Conclusion: Fospropofol provides better suppression of the stress response during tracheal intubation and positioning. It also significantly reduces the incidence of myoclonus and demonstrates favorable hemodynamic stability though its slower onset and higher incidence of pruritus require clinical consideration. Clinical Trial Registration: Registered at: https://www.isrctn.com/, ISRCTN12170320, registration date: 24/06/2025.
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