ArticleFrontiers in oncology2026
Long term survival of patients with alpha-fetoprotein-positive hepatoid adenocarcinoma of the gallbladder: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hepatoid adenocarcinoma (HAC) of the gallbladder is an exceedingly rare and highly aggressive variant of gallbladder carcinoma that is frequently associated with alpha-fetoprotein (AFP) production and typically has a poor prognosis. We report a 66-year-old male with a two-week history of right upper abdominal pain. Imaging revealed a hypermetabolic mass at the gallbladder fundus, accompanied by a significantly elevated serum AFP concentration of 1210.00 ng/mL. Histopathological and immunohistochemical analyses confirmed a diagnosis of AFP-positive HAC. Notably, next-generation sequencing (NGS) revealed a
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