Evidence map›Paper›PMID 42453856›Full record

ReviewF1000Research2026

Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci.

Sristi Dey, Sophie A Krivograd, Britta E Rued

Abstract readReview
In one paragraph

Review in F1000Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sristi DeyVeterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa, 50010, USA.ORCID https://orcid.org/0009-0005-6472-8820
Sophie A KrivogradVeterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa, 50010, USA.ORCID https://orcid.org/0009-0008-4079-3806
Britta E RuedVeterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa, 50010, USA.ORCID https://orcid.org/0000-0003-3178-4269

Funding

Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiomeR00DE032311 · NIDCR · IOWA STATE UNIVERSITY · PI Britta Rued · 2024 to 2026
$747k
NIDCR NIH HHS R00 DE032311
6 · The paper itself

Abstract

Streptococci are prevalent in animal and human microbiomes. These organisms produce a vast array of small peptides that modulate complex functions within the cell such as quorum sensing, virulence, and metabolism. Transcriptional regulators are central to this process, of which Rgg transcriptional regulators hold prominence in streptococci. These systems are controlled by peptides known as SHPs (short hydrophobic peptides) and LCPs (leaderless communication peptides). Also known as Rgg/SHP quorum sensing (QS) systems, they are ubiquitous across streptococcal species and regulate cellular competence, metabolic programs, virulence, and facilitate colonization of host species. It has been recently demonstrated that Rgg/SHP QS systems can also regulate the production of natural products known as RaS-RiPPs (

Indexed as

Bacterial Proteinsras ProteinsStreptococcusTrans-ActivatorsAnimalsGene Expression Regulation, BacterialHumansQuorum SensingBacterial Proteinsras Proteinsrgg protein, StreptococcusTrans-Activatorscompetencequorum sensingRaS-RiPPsRgg/SHPStreptococci

Identifiers

PMID42453856
PMCPMC13361665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.