ArticleOpen forum infectious diseases2026
Accuracy and Usability of a New Rapid Diagnostic Test for the Diagnosis of Dengue in Vientiane, Laos.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: An estimated 390 million dengue virus (DENV) infections occur per year, 70% in the Western Pacific and Southeast Asia. A prototype rapid diagnostic test (RDT) (NS1, immunoglobulin M [IgM]/immunoglobulin G [IgG]; DengueDx, Mologic) was evaluated for accuracy and ease of use for dengue diagnosis at Mahosot Hospital, Vientiane, Lao People's Democratic Republic. Methods: Five hundred twenty-six sera collected in 2017 and 2018 from patients hospitalized with suspected dengue were included. Prototype RDT results were compared to NS1 and IgM enzyme-linked immunosorbent assays and/or real-time reverse-transcription polymerase chain reaction as reference assays and to Bioline dengue RDT (NS1, IgM/IgG) as comparator. The accuracy of the image-based result interpretation (RDT scan or photograph) at day 0 and after a delay of 7 days was evaluated. Five technicians were observed when performing RDTs and interviewed on their perception of the ease of use. Results: The overall sensitivity and the sensitivity for NS1 detection alone were significantly lower for the prototype RDT (65.2% [95% confidence interval {CI}, 59.3%-70.8%] and 44.6% [95% CI, 38.0%-51.4%], respectively) than for the Bioline RDT (76.7% [95% CI, 69.1%-83.2%], z-test Conclusions: Improvement in test sensitivity and in device design would adapt the prototype RDT for Laos and similar contexts. Optimization of the prototype RDT is warranted and further evaluation in different healthcare settings would provide a more accurate estimation of the value of this RDT for dengue surveillance in remote areas.
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