Evidence map›Paper›PMID 42453690›Full record

ReviewPatterns (New York, N.Y.)2026

Design principles for integrated AI alignment.

Ben Y Reis, William G La Cava

Abstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ben Y ReisComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
William G La CavaComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.

Funding

Real-time Monitoring and Correction of Clinical Decision Support Systems using Artificial IntelligenceR01LM014300 · NLM · BOSTON CHILDREN'S HOSPITAL · PI William La Cava · 2024 to 2026
$2.1M
NLM NIH HHS R01 LM014300
6 · The paper itself

Abstract

As AI adoption accelerates across human society, the problem of aligning AI models with human preferences remains a grand challenge. Currently, the AI alignment field is deeply divided between behavioral and representational approaches, resulting in narrowly aligned models that are more vulnerable to increasingly deceptive misalignment threats. In the face of this fragmentation, we propose an integrated vision for the future of the field. Drawing on related lessons from immunology and cybersecurity, we lay out a set of design principles for the development of integrated alignment frameworks that combine the complementary strengths of diverse alignment approaches through deep integration and adaptive coevolution. We highlight the importance of strategic diversity-deploying orthogonal alignment and misalignment detection approaches to avoid homogeneous pipelines that risk being "doomed to success." We also recommend steps for greater unification of the AI alignment research field itself, through cross-collaboration, open model weights, and shared community resources.

Identifiers

PMID42453690
PMCPMC13366518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.