Evidence map›Paper›PMID 42453688›Full record

ReviewPatterns (New York, N.Y.)2026

Multimodal spatial omics: From data acquisition to computational integration.

Esra Busra Isik, Yusuf Hakan Usta, Maryam Riazi, Haozhe Liu, William Roach, Hongpeng Zhou, Anna Nicolaou, Magnus Rattray, Sokratia Georgaka

Abstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Esra Busra IsikDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.
Yusuf Hakan UstaDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.
Maryam RiaziDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.
Haozhe LiuDepartment of Computer Science, University of Manchester, Manchester, UK.
William RoachDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.
Hongpeng ZhouDepartment of Computer Science, University of Manchester, Manchester, UK.
Anna NicolaouDivision of Pharmacy & Optometry, School of Health Sciences, and Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Magnus RattrayDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.
Sokratia GeorgakaDivision of Informatics, Imaging & Data Sciences, School of Health Sciences, University of Manchester, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent developments in spatial omics technologies have enabled the generation of high-dimensional molecular data, including transcriptomics, proteomics, and epigenomics, within their spatial tissue context, either through co-profiling on the same slice or through profiling across serial tissue sections. These datasets, which are often complemented by images, have given rise to multimodal frameworks that capture both the cellular and architectural complexity of tissues across multiple molecular layers. Integration of such multimodal data poses significant computational challenges due to differences in scale, resolution, and data modality. In this review, we present a comprehensive overview of computational methods developed to integrate multimodal spatial omics and imaging datasets. We highlight key algorithmic principles underlying these methods, ranging from probabilistic to the latest deep learning approaches.

Indexed as

computational methodsdeep learningmatrix factorizationmultimodal integrationoptimal transportspatial omics

Identifiers

PMID42453688
PMCPMC13366528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.