Evidence map›Paper›PMID 42453680›Full record

ArticleACS catalysis2025

Cu-Catalyzed Three-Component Carbofunctionalization of 1,3-Dienes.

Vincent R Viviani, Travis L Buchanan, An Thien Ho, John A Little, Andrei G Popov, Matthew Barnett, Kira Q McMahon, Samuel N Gockel, Kami L Hull

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Alcohol-Directed Carboamination of Conjugated Enynes.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vincent R VivianiDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0009-0004-5741-3946
Travis L BuchananDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-9038-9790
An Thien HoDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-3931-2303
John A LittleDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-5896-138X
Andrei G PopovDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0009-0001-7385-4838
Matthew BarnettDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Kira Q McMahonDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Samuel N GockelDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States; Current Address: Colorado State University Pueblo, 2200 Bonforte Blvd, Pueblo, CO 81001.
Kami L HullDepartment of Chemistry, The University of Texas at Austin, Austin, Texas, 78712, United States.ORCID 0000-0003-3102-2686

Funding

Transition Metal-Catalyzed Alkene FunctionalizationR35GM125029 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Kami Lee Hull · 2017 to 2026
$2.7M
NIGMS NIH HHS R35 GM125029
6 · The paper itself

Abstract

The carboamination of 1,3-dienes provides direct and efficient access to allylic amines in a step-economical fashion. Herein, we disclose a three-component 1,3-diene carboamination reaction that provides modular access to a multitude of allylic amines. A representative scope 1,3-dienes, activated alkyl halides, and amines are demonstrated to serve as components for this reaction with yields ranging from up to 96%. High regioisomeric ratios are observed with both substituted and unsubstituted diene derivatives for either 1,2- or 1,4-carboamination (≥12:1). Mechanistic investigations demonstrate that the reaction proceeds via atom transfer radical addition (ATRA) to the diene, affording an isolable allylic halide intermediate. The scope was expanded to a general carbofunctionalization, by adding an exogenous O, S, P, or C nucleophile and base, to the reaction upon formation of the allylic halide, in a two-step, one-pot process.

Indexed as

atom transfer radical additionCarbofunctionalizationconjugated dienescopper catalysismulticomponent functionalization

Identifiers

PMID42453680
PMCPMC13367458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.