Evidence map›Paper›PMID 42453674›Full record

ArticleFrontiers in nutrition2026

WWP1 modulates metabolic adaptation in white adipose tissue but does not significantly modify caloric restriction-induced longevity in mice.

Yuka Nozaki, Kumi Miura, Kenta Yajima, Shunsuke Hoshino, Shoma Tamori, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuka Nozaki *Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Kumi Miura *Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Kenta Yajima *Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Shunsuke Hoshino *Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Shoma TamoriFaculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Yuhei MizunoeFaculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Masaki KobayashiDivision of Aging Biology, Research Institute for Science and Technology (RIST), Tokyo University of Science, Tokyo, Japan.
Yoshikazu HigamiFaculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caloric restriction (CR) extends lifespan across diverse species. While the WW domain-containing E3 ubiquitin ligase1 (WWP1) is an essential mediator of dietary restriction-induced longevity in

Indexed as

caloric restrictionde novo fatty acid synthesislongevitymiceWWP1

Identifiers

PMID42453674
PMCPMC13364857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.