Evidence map›Paper›PMID 42453408›Full record

ArticleActa pharmaceutica Sinica. B2026

Harnessing the spleen-brain axis: Magnolol-loaded nanomedicine attenuates ischemic stroke

Yane Li, Li Yao, Jiaxuan Hou, Xingyun Yuan, Yuanyuan Zhu, Zhichao Deng, Chenxi Xu, Jinxing Chen, Bingyi Chen, Jiayan Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yane LiDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Li YaoDepartment of Neurology, XD Group Hospital, Xi'an 710077, China.
Jiaxuan HouDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Xingyun YuanDepartment of Neurology, The First People's Hospital of Xianyang, Xianyang 712000, China.
Yuanyuan ZhuSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Zhichao DengSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Chenxi XuSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Jinxing ChenDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Bingyi ChenDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Jiayan LiDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Yifan MeiDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Shuang LiuDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Shaoying LuDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Mingzhen ZhangSchool of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
Hui CaiDepartment of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia-reperfusion (I/R) injury is exacerbated by the infiltration of splenic monocytes/macrophages (Mo/M

Indexed as

Cerebral ischemia–reperfusion injuryIschemic strokeLiposomesMacrophage polarizationMagnololOxidative stressSpleen–brain axisSplenic monocytes/macrophages

Identifiers

PMID42453408
PMCPMC13366309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.