ArticleBiomaterials research2026
Sonodynamic CoMg-Quercetin Nanozyme for Antibacterial Therapy and Multifunctional Bone Regeneration in Infectious Bone Defects.
Article in Biomaterials research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Infectious bone defects remain a serious clinical challenge because infection-associated inflammation markedly hinders bone regeneration. To address this complicated pathological condition, a porphyrin-doped cobalt-magnesium bimetallic quercetin-based sonosensitive nanozyme (CoMg-Que) was engineered to integrate antibacterial therapy, redox modulation, and tissue regenerative functions within a single platform. Upon ultrasound (US) irradiation, CoMg-Que was activated and efficiently generated reactive oxygen species (ROS) for sonodynamic antibacterial treatment. Following termination of US stimulation, its inherent superoxide dismutase- and catalase-like activities further removed excessive ROS, thereby relieving inflammatory responses and re-establishing redox homeostasis. In vitro experiments demonstrated that CoMg-Que effectively eliminated methicillin-resistant
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