Evidence map›Paper›PMID 42453341›Full record

ArticleACS pharmacology & translational science2026

Activation of the Aryl Hydrocarbon Receptor-Cytochrome P450 1A1 Axis Mediates the Selective Cytotoxicity of 2‑Phenyl-Imidazo[1,2‑

Lo-Wei Lin, Carley E Beeman, Jun Yang, Arpa Ebrahimi, Simone Büchel, Christoph W Grathwol, Nicole Jung, Stefan Bräse, David A Hendrix, Claudia S Maier and 2 more

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lo-Wei LinDepartment of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0000-0002-0876-7826
Carley E BeemanDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.
Jun YangDepartment of Biochemistry & Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.
Arpa EbrahimiDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0009-0004-3454-2112
Simone BüchelInstitute of Biological & Chemical SystemsFunctional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.
Christoph W GrathwolInstitute of Biological & Chemical SystemsFunctional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-0232-3279
Nicole JungInstitute of Biological & Chemical SystemsFunctional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-9513-2468
Stefan BräseInstitute of Biological & Chemical SystemsFunctional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-4845-3191
David A HendrixDepartment of Biochemistry & Biophysics, Oregon State University, Corvallis, Oregon 97331, United States.
Claudia S MaierDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0000-0003-0743-8956
Andrew C B CatoInstitute of Biological & Chemical SystemsFunctional Molecular Systems, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-8508-3834
Siva K KolluriDepartment of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, United States.ORCID https://orcid.org/0000-0003-1031-9827

Funding

MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with poor clinical outcomes and limited treatment options. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates xenobiotic metabolism through the induction of many cytochrome P450 enzymes such as CYP1A1. In this study, we investigated three 2-phenyl-imidazo-[1,2-

Indexed as

aryl hydrocarbon receptorcytochrome P450 1A1DNA damageimidazopyridine derivativesmetabolic activationtriple-negative breast cancer cells

Identifiers

PMID42453341
PMCPMC13366347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.