Evidence map›Paper›PMID 42453340›Full record

ReviewACS pharmacology & translational science2026

Recent Developments in the Diagnosis and Treatment of Disseminated and Rare Melanoma with Radiotheranostics.

Rüdiger M Exner, Jason S Lewis, Lisa Bodei, Naga Vara Kishore Pillarsetty

Abstract readReview
In one paragraph

Review in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rüdiger M ExnerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0002-9415-382X
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0001-7065-4534
Lisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0001-6930-7383
Naga Vara Kishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0002-1750-7436

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

Disseminated melanoma, particularly of rare subtypes such as mucosal or uveal melanoma, is a difficult to treat, deadly disease characterized by poor median survival and resistance to a wide range of treatments. Despite new approvals, such as novel immunotherapeutics, there is a significant need for effective therapeutic modalities. Given the successes in the development of targeted radiopharmaceutical diagnostic agents and therapies for other cancers (the so-called theranostics), assessing the efficacy of these strategies in the context of melanoma appears as the next logical step. Here we aim to provide an overview of recent advances in the development of preclinical and clinical melanoma-specific radiopharmaceuticals. Where applicable, we will highlight their relevance in the context of rare subtypes of melanoma.

Indexed as

melanomanuclear imagingradioligandsradiotheranosticsradiotherapyrare cancers

Identifiers

PMID42453340
PMCPMC13366344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.