Evidence map›Paper›PMID 42453337›Full record

ArticleACS pharmacology & translational science2026

Identifying Antibiotic Effects of Investigational Drugs on Commensal Bacteria with Machine Learning.

Hrshita Gowda, Wenbo Lu, Paul Skaluba, Yan Xiang, Jessica R McCann, Laura E McCoubrey, John F Rawls, Ophelia S Venturelli, Daniel Reker

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hrshita GowdaDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.
Wenbo LuDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0003-4913-2453
Paul SkalubaDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.
Yan XiangDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0003-4796-2912
Jessica R McCannDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710, United States.
Laura E McCoubreyUCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, U.K.
John F RawlsDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710, United States.
Ophelia S VenturelliDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.
Daniel RekerDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0003-4789-7380

Funding

Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiotaR35GM124774 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Ophelia Venturelli · 2017 to 2026
$2.9M
Model-guided design of next-generation bacterial therapeutics to treat cardiovascular diseaseR01EB030340 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI REY, FEDERICO E, ROMERO, PHILIP ANTHONY · 2020 to 2023
$2.8M
Genetic determinants of Bacteroides vulgatus colonization fitness and host inflammatory responsesR01DK136231 · NIDDK · DUKE UNIVERSITY · PI John F Rawls · 2023 to 2026
$2.6M
NIBIB NIH HHS R01 EB030340NIDDK NIH HHS R01 DK136231NIGMS NIH HHS R35 GM124774
6 · The paper itself

Abstract

Many human-targeted medications have been found to impact patients' gastrointestinal microbiomes, which has been proposed as an unrecognized source of drug side effects, comorbidities, and reduced treatment efficiencies. However, current methods for detecting such effects, such as patient sample analysis or

Indexed as

antibiotic discoveryantibiotic resistancecommunity dynamicsdrug-microbiome interactionsmachine learningstructure activity relationship

Identifiers

PMID42453337
PMCPMC13366338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.