ArticleBiomedical reports2026
Carbamazepine-induced Stevens-Johnson syndrome in Chinese with negative HLA-A*3101 and HLA-B*1502 genes: A case report.
Article in Biomedical reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Stevens-Johnson syndrome (SJS) is a severe, potentially life-threatening disease primarily induced by medications, which often involves lesions of the oral mucosa, eyes and skin. Its pathogenesis is partially associated with genetic factors. The present study reported a case of SJS following oral administration of carbamazepine (CBZ). A total of ~2 weeks after initiating the medication, the patient developed generalized skin rashes with pruritus, which progressively evolved into patchy erythema on the face, neck, chest, back, oral cavity and lips; oral herpes also emerged. As the condition advanced, the patient experienced blurred vision, along with rupture and exudation of the oral and labial herpes. The patient was diagnosed with SJS. However, genotyping results revealed a negative status for both major histocompatibility complex, class I, A (HLA-A)
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