ArticlePediatrics open science2026
Sodium Supplementation Algorithm to Promote Growth in Infants Who Are Preterm: Randomized Clinical Trial.
Article in Pediatrics open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectiveEvaluate the effectiveness of an algorithm using urine sodium (Na) concentration to guide dietary Na supplementation compared with standard care to promote growth in infants who are preterm.
methodsA randomized trial was conducted in 4 neonatal units in Indianapolis, Indiana, involving infants between 25
resultsOf 260 eligible infants, 90 were consented and randomized, with 45 allocated to each arm and 43 in each arm completing the study. Thirty-eight (88%) infants randomized to the study algorithm had a low urine Na that qualified for Na supplementation (4 mEq/kg/d). Infants assigned the algorithm received more Na (5.75 ± 0.96 mEq/kg/d) than infants assigned the standard care (3.62 ± 1.25 mEq/kg/d); caloric intake did not differ. Change in weight Z-score from study entry until 36 weeks PMA was not statistically different between groups (0.16 ± 0.41 vs 0.04 ± 0.63, algorithm vs control;
conclusionNa supplementation guided by urine Na concentration did not significantly improve weight gain in infants 25
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