Evidence map›Paper›PMID 42453244›Full record

ArticleJournal of family medicine and primary care2026

Acute methemoglobinemia- Diagnosing and managing in family practice.

Raj D Vyas

Abstract readCase Reports
In one paragraph

Article in Journal of family medicine and primary care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Raj D VyasDepartment of Family Medicine, Vadamalayan Hospital, Dindigul, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methemoglobinemia is a rare but serious disorder in which hemoglobin is oxidized to methemoglobin, impairing oxygen transport. This condition can present in primary care with cyanosis and oxygen desaturation and is potentially misdiagnosed as respiratory or cardiac failure. We present the case of a 38-year-old male driver who was brought to the emergency department unconscious, with cyanosis, and unresponsive to oxygen therapy. His oxygen saturation was 86% on pulse oximetry, although arterial blood gas analysis showed a normal partial pressure of oxygen. The source of poisoning was unknown at the time of admission. Subsequent co-oximetry testing revealed elevated methemoglobin (MtHb) levels (64.8%), confirming a diagnosis of methemoglobinemia. Immediate treatment with intravenous methylene blue resulted in a prompt clinical recovery, with a return to consciousness and normalization of methemoglobin levels within hours. This case highlights the importance of considering methemoglobinemia in patients presenting with unexplained unconsciousness and cyanosis. Early diagnosis and treatment, even when the source of poisoning is unclear, are key to preventing complications and improving patient outcomes.

Indexed as

Blood gasco-oximetrycyanosisfamily medicinefamily practicemethemoglobinemiamethylene blueprimary care

Identifiers

PMID42453244
PMCPMC13367618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.